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５０天龄雌性ＳＤ大鼠随机分为４组，每组２５只。Ⅰ组每只大鼠一次灌胃给予ＤＭＢＡ１０ｍｇ；Ⅱ组给ＤＭＢＡ前饮水中加ＣＨＬ１．５ｍｍｏｌ／Ｌ，持续１ｗｋ；Ⅲ组给ＤＭＢＡ后饲料中加ＢＣ９０ｍｇ／ｋｇ饲料，持续到实验结束；Ⅳ组给ＤＭＢＡ前后分别给ＣＨＬ和ＢＣ。结果各组的肿瘤发生率分别为５０．０％，３３．３％，１８．３％和１７．４％。给ＢＣ组肿瘤发生率低于对照组（Ｐ＜０．０５），而单给ＣＨＬ组的肿瘤发生率与对照组比较差异无显著性（Ｐ＞０．０５），ＣＨＬ与ＢＣ合用组肿瘤发生率与Ⅲ组相似。说明ＢＣ确有抑制ＤＭＢＡ诱发乳腺癌的作用，而ＣＨＬ单用对ＤＭＢＡ的致癌作用无明显抑制，ＣＨＬ与ＢＣ合用也无协同或相加作用。
50-day-old female Sprague-Dawley rats were randomly divided into 4 groups of 25 rats. Group Ⅰ rats were given intragastric administration of DMBA 10mg once a day; Group Ⅱ was given CHL 1.5mmol / L before DMBA drinking water for 1 week; Group Ⅲ was given BC90mg / kg diet supplemented with DMBA for the end of the experiment; Group Ⅳ Before and after DMBA to CHL and BC. Results The incidence of tumor in each group was 50.0%, 33.3%, 18.3% and 17.4% respectively. The incidence of tumor in BC group was lower than that in control group (P <0.05), while the incidence of tumor in CHL group was not significantly different from that in control group (P> 0.05) Rate and group Ⅲ similar. BC did inhibit the DMBA-induced breast cancer role, and CHL alone on the carcinogenicity of DMBA no significant inhibition, CHL and BC combination no synergistic or additive.