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用琼脂糖凝胶电泳的方法检测分离自我国各疫源地，１７个生态型的２００６株鼠疫菌的大质粒。结果表明，我国鼠疫菌含具有分类属性的大质粒共三类（５２，６５，９２Ｍｄ）。６５Ｍｄ质粒在各疫源地均有分布，５２、９２Ｍｄ质粒仅存在于青藏高原喜马拉雅旱獭疫源地。含５２Ｍｄ质粒的菌株分布在祁连山南、北麓及青海湖的环湖地区，带９２Ｍｄ质粒的菌株则分布在西藏那曲周围的唐古拉地区及青海的玉树、曲麻莱等地。鉴于这两类质粒有其独特的分布区，可将大质粒分子量的差异作为青藏高原喜马拉雅旱獭疫源地内区分鼠疫菌生物亚型的指标之一。
The agarose gel electrophoresis method was used to detect the large plasmids of 2006 Y. pestis isolated from 17 endemic areas in China. The results showed that there are three types of large-sized plasmids (52,65,92Md) in Y. pestis in our country. The 65Md plasmid was distributed in all kinds of foci. The 52,92Md plasmid existed only in the Himalayan marmot of Qinghai-Tibet Plateau. Strains with 52Md plasmid were distributed in the south of the Qilian Mountains, the northern foot of the lake and the lake in Qinghai Lake. Strains with 92Md plasmids were found in the Tangula region around Nagqu, Tibet and Yushu and Qumalai in Qinghai. In view of the unique distribution of these two types of plasmids, the difference in the molecular weight of the large plasmids can be used as one of the indicators for distinguishing the Yersinia pestis isolates from the Hmrya marmota in the Qinghai-Tibet Plateau.