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探讨３－硝基三氮唑衍生物的放射增敏作用，并对其生物学效应作出评价。方法本文用克隆形成法研究了２２个３－硝基－１，２，４－三氮唑衍生物的体外放射增敏活性和乏氧、富氧细胞毒性。结果两个化合物的活性胜过ＭＩＳＯ，有三个化合物与ＭＩＳＯ和ＳＲ－２５０８相当，其余的其活性均较低。３－硝基三唑衍生物也像２－硝基咪唑类那样，其放射增敏活性与电子亲和性（用半波还原电位Ｅ１／２表示）有关。亲和性越大，即Ｅ１／２值越偏正，增敏活性越强。环核Ｎ１位和５位上取代基的结构和性质影响着化合物的Ｅ１／２、分配系数ｐ和细胞毒性。结论３－硝基三唑衍生物对乏氧和富氧（空气）细胞的毒性差别是很有限的，所以它们不是有效的乏氧调节细胞毒剂。但某些的放射增敏作用是值得深入研究的。
To investigate the radiosensitization of 3-nitrotriazole derivatives and to evaluate their biological effects. Methods In this study, 22 3-nitro-1,2,4-triazole derivatives were studied in vitro for their radiosensitizing activity and hypoxia-enriched and cytotoxicity. As a result, the two compounds were more active than MISO, with three compounds comparable to MISO and SR-2508, with the remaining less active. The 3-nitrotriazole derivatives are also related to the radiosensitizing activity as the 2-nitroimidazoles and the electron affinity (represented by the half-wave reduction potential E1 / 2). The greater affinity, that is, the more positive E1 / 2 value, the stronger the sensitizing activity. The structure and properties of the substituents at the N1 and 5 positions of the cyclic nuclei affect the E1 / 2, partition coefficient p and cytotoxicity of the compounds. Conclusions 3-Nitrotriazole derivatives are very limited in their toxicity to hypoxia and oxygen-enriched (air) cells, so they are not potent hypoxia-regulating cytotoxic agents. However, some radiosensitization is worth further study.