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目的 :通过大鼠急性坏死型胰腺炎 ( ANP)模型 ,观察血液中 TAX2 、PGI2 、PGE2 的含量变化 ,及其经奥曲肽治疗后的变化 ,以探讨 ANP的发病机制以及奥曲肽治疗ANP的可能机理。方法 :实验分空白对照组、模型组和治疗组共 2 4只大鼠 ,分别观察其病理变化及测定血液中 TXA2 的稳定产物 TXB2 、PGI2 的稳定产物 PGF1α及 PGE2 的含量。结果 :发生 ANP后大鼠血浆中 TXB2 含量显著升高 ,经奥曲肽治疗后有明显下降 ( P均 <0 .0 1 ) ;而 PGF1α则显著下降 ,经奥曲肽治疗后又得到明显上升 ( P均 <0 .0 1 )。 PGE2 则无明显改变。( P均 >0 .0 5)。结论 :证实了大鼠 ANP时发生了前列腺素水平的变化 ,TXB2 、PGI2 参与了 ANP的致病过程。奥曲肽在治疗 ANP的机制中有调理 TXB2 / PGI2 浓度的作用 ,可能为奥曲肽治疗 ANP机理之一。
OBJECTIVE: To investigate the changes of TAX2, PGI2 and PGE2 in blood after acute necrotic pancreatitis (ANP) in rats and to explore the possible mechanism of ANP by investigating the pathogenesis of ANP. Methods: The experiment was divided into blank control group, model group and treatment group, a total of 24 rats were observed pathological changes and determination of blood TXB2 stable products TXB2, PGI2 stable products PGF1α and PGE2 content. Results: After ANP, the content of TXB2 in plasma significantly increased (P <0.01), while PGF1α decreased significantly after treatment with octreotide (P < 0 .0 1). PGE2 no significant change. (P> 0.05). Conclusion: The changes of prostaglandin level in rat ANP were confirmed. TXB2 and PGI2 were involved in the pathogenesis of ANP. Octreotide in the treatment of ANP mechanism of TXB2 / PGI2 concentration of the role of regulation may be one of the mechanisms of octreotide treatment of ANP.