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目的 :研究重型肝炎患者血清血管内皮细胞生长因子 (VEGF)的含量与重型肝炎预后的关系。方法 :采用ELISA定量检测55例重型肝炎患者 (其中急性重型肝炎 2例 ,亚急性重型肝炎 9例 ,慢性重型肝炎 44例 )及健康体检者血清VEGF含量。结果 :正常对照组、重型肝炎患者存活组、死亡组血清VEGF含量分别为 :44.73± 1 4 .71pg/ml,80 .48± 1 0 .47pg/ml,37.99± 1 2 .70pg/ml。提示重型肝炎患者存活组血清VEGF水平与正常对照组相比显著升高 (P <0 .0 5) ,死亡组略降低但无统计学意义 (P >0 .0 5)。结论 :(1 )VEGF与肝细胞再生密切相关 ;(2 )动态检测血清VEGF水平变化可以预测重型肝炎患者的预后
Objective: To study the relationship between the serum levels of vascular endothelial growth factor (VEGF) and the prognosis of severe hepatitis in patients with severe hepatitis. Methods: Serum VEGF levels in 55 patients with severe hepatitis (including 2 acute severe hepatitis, 9 acute sub-acute hepatitis and 44 chronic severe hepatitis) were detected by ELISA. Results: The levels of serum VEGF in survivors and death patients in normal control group and severe hepatitis group were 44.73 ± 14.71 pg / ml, 80.48 ± 1.047 pg / ml and 37.99 ± 1.27 pg / ml, respectively. The serum level of VEGF in survivors with severe hepatitis was significantly higher than that in the control group (P <0.05), while the death group was slightly lower but not statistically significant (P> 0.05). Conclusions: (1) VEGF is closely related to hepatocyte regeneration; (2) dynamic detection of serum VEGF levels can predict the prognosis of patients with severe hepatitis