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多数淋巴母细胞、白细胞及重组干扰素α_(2a、2b)治疗慢性乙肝对照研究显示,干扰素可使病毒DNA或DNA多聚酶消失,但成功率仅为40％～60％,且费用昂贵,副作用明显,故有必要建立一个更能接受、更有效的治疗方案。 材料与方法:56例患者入选:年龄18～70岁,谷丙转氨酶至少是正常值上限的两倍,反复检查证实HBV感染至少已6个月,近3个月内活检表明为慢活肝。患者随机分为三组:A组,先2周60 mg强的松,后2周减至25 mg,再停用任何药物,2周后皮下注射4个月的重组干扰素α2b(intronA),每次剂量1.5 MU,每
Most lymphoblasts, leukocytes and recombinant interferon α_ (2a, 2b) treatment of chronic hepatitis B control studies have shown that interferon can make viral DNA or DNA polymerase disappear, but the success rate of only 40% to 60%, and expensive, side effects Obviously, it is necessary to establish a more acceptable and more effective treatment options. MATERIALS AND METHODS: Sixty-six patients were enrolled: alanine aminotransferase at least twice the upper limit of normal, ages 18-70 years, repeated examinations to confirm HBV infection for at least 6 months and biopsy in nearly 3 months as slow living liver. Patients were randomized into three groups: group A, 60 mg prednisone for 2 weeks followed by 25 mg reduction for 2 weeks, then discontinued for any drug, subcutaneous injection of 4 months of recombinant interferon alpha 2b (intron A) 2 weeks later, Each dose 1.5 MU, each