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目的了解2011-2014年荆州地区婴幼儿HCMV感染现状及其与母婴传播的关系。方法应用荧光定量聚合酶链式反应(FQ-PCR)检测409例尿液样本及295例乳汁样本的HCMV-DNA,其中母子配对样本295例。结果 409例尿液样本中,HCMV-DNA阳性59例,阳性率14.43%;各年龄段和不同年份感染率均有统计学差异(P<0.01),HCMV感染率无性别差异(P>0.05);295例母乳HCMV-DNA阳性产妇喂养的婴儿中,尿液HCMV-DNA阳性率(19.0%)明显高于母乳阴性喂养的婴儿(6.0%)。结论荆州地区婴幼儿有较高的HCMV感染率,且呈逐年上升的趋势;母婴传播是婴幼儿感染HCMV途径之一。
Objective To understand the status of HCMV infection in infants and young children in Jingzhou from 2011 to 2014 and its relationship with mother-to-infant transmission. Methods HCMV-DNA was detected in 409 urine samples and 295 breast milk samples by fluorescence quantitative polymerase chain reaction (FQ-PCR), of which 295 matched maternal and paired samples. Results The positive rate of HCMV-DNA in 409 urine samples was 14.43%. There was a significant difference in infection rates among all age groups and years (P <0.01). There was no gender difference in HCMV infection rate (P> 0.05) The positive rate of HCMV-DNA in urine (29.0%) in 295 mothers with HCMV-DNA positive mothers was significantly higher than that in mothers with negative HCMV-DNA (6.0%). Conclusion The infants and young children in Jingzhou have a higher infection rate of HCMV, which shows an increasing trend year by year. Maternal-to-infant transmission is one of the pathways of HCMV infection in infants and young children.