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目的探讨1,6-二磷酸果糖治疗慢性心力衰竭的临床疗效。方法将60例慢性心衰患者随机分为两组,每组30例,对照组常规应用抗心力衰竭治疗,包括应用洋地黄、利尿剂、ACEI和硝酸酯类药物;治疗组在对照组的基础上加用1,6-二磷酸果糖,10g静滴,每天1次。两组疗程均为2周。观察两组治疗后的临床疗效、左心室射血分数、心排出量及血液动力学指标。结果治疗组显效22例,有效7例,无效1例,总有效率96.7%。对照组显效13例,有效9例,无效8例,有效率73.3%。两组比较差异有显著性,P<0.05。结论1,6-二磷酸果糖作为一种重要的细胞内中间代谢供能物质,能增加心肌收缩力,改善充血性心力衰竭患者的心脏功能,与传统抗心衰药物合用能产生良好的协同作用,可以作为常规心力衰竭治疗的补充和辅助用药。
Objective To investigate the clinical efficacy of fructose-1,6-diphosphate in the treatment of chronic heart failure. Methods Sixty patients with chronic heart failure were randomly divided into two groups (n = 30 in each group). The control group was given routine anti-heart failure treatment, including digitalis, diuretics, ACEI and nitrates. The treatment group was basal in the control group Addition of fructose 1,6-diphosphate, 10g intravenous infusion, 1 day. Two groups of treatment are 2 weeks. The clinical efficacy, left ventricular ejection fraction, cardiac output and hemodynamic parameters were observed after treatment. Results The treatment group was effective in 22 cases, effective in 7 cases, ineffective in 1 case, the total effective rate was 96.7%. In the control group, 13 cases were markedly effective, 9 cases effective, 8 cases ineffective, and the effective rate was 73.3%. The difference between the two groups was significant, P <0.05. Conclusion Fructose 1, 6-diphosphate as an important intracellular metabolic energy supply substance can increase myocardial contractility, improve heart function in patients with congestive heart failure, and with traditional anti-heart failure drugs can produce good synergy , Can be used as a supplement to conventional heart failure treatment and adjuvant therapy.