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目的观察红花黄色素联合二甲双胍治疗早期糖尿病肾病(DN)的临床疗效。方法 DN患者80例随机分为对照组和观察组,每组40例,2组均接受常规治疗,对照组在常规治疗基础上口服盐酸二甲双胍治疗,观察组在对照组基础上静脉滴注红花黄色素。疗程均为2周。观察2组临床疗效及空腹血糖(FBG)、餐后2 h血糖(2 h PG)、三酰甘油(TG)、胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、全血低切黏度、全血中切黏度、全血高切黏度、血浆黏度变化。结果观察组总有效率高于对照组,差异有统计学意义(P<0.05)。与治疗前比较,2组治疗后FBG、2 h PG、TC、TG、LDL-C、全血高切黏度、血浆黏度明显降低,观察组全血低切黏度、全血中切黏度也明显降低,且观察组上述指标降低程度优于对照组(P<0.05)。2组治疗期间均未发生明显不良反应。结论红花黄色素联合二甲双胍治疗早期糖尿病肾病能够显著降低患者血糖、血脂水平,改善血液高黏状态,值得临床推广应用。
Objective To observe the clinical efficacy of safflor yellow combined with metformin in the treatment of early diabetic nephropathy (DN). Methods Eighty patients with DN were randomly divided into control group and observation group, 40 cases in each group. Both groups received routine treatment. The control group was treated with metformin hydrochloride on the basis of conventional treatment. The observation group received intravenous drip of safflower Yellow pigment. The course of treatment is 2 weeks. The clinical effects, fasting blood glucose (FBG), 2 h PG, triglyceride (TG), cholesterol, low density lipoprotein cholesterol (LDL-C) Viscosity, whole blood shear viscosity, whole blood high shear viscosity, plasma viscosity changes. Results The total effective rate in the observation group was higher than that in the control group, with significant difference (P <0.05). Compared with those before treatment, the levels of FBG, 2 h PG, TC, TG, LDL-C, whole blood high shear viscosity and plasma viscosity were significantly decreased in both groups after treatment, and the whole blood low shear viscosity and whole blood shear viscosity were significantly decreased , And the above indicators in the observation group decreased more than the control group (P <0.05). No significant adverse reactions occurred in the two groups during the treatment. Conclusion Safflower yellow combined with metformin in early diabetic nephropathy can significantly reduce blood glucose and blood lipid levels and improve blood viscosity state, which is worthy of clinical application.