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吡哌酸(Pipemidic Acid)简称PPA,是一种新型合成抗菌药,不溶于水及一般有机溶剂,而溶于矿酸及氢氧化碱溶液.我们就其在不同pH值缓冲液中及不同介质中的溶解度进行实验,为其注射剂等液体剂型的制备及生物利用度的研究提供依据,并用溶解度法求得吡哌酸的pKa值和等电点。仪器及试剂 75-2型分光光度计(上海分析仪器三厂);LD4-2A型离心机(北京医用离心机厂);PHS-2型酸度计(上海雷磁仪器厂);电动振荡机(盐城龙岗医疗器械厂);吡哌酸及其标准品(山东新华药厂提供);葡萄糖酸
Pipemidic Acid, abbreviated as PPA, is a new type of synthetic antibacterial agent that is insoluble in water and common organic solvents but dissolves in mineral acids and alkali hydroxide solutions. We tested its performance in different pH buffers and different media In order to provide basis for preparation of liquid dosage forms such as injections and bioavailability studies. The pKa value and isoelectric point of pipemidic acid were determined by solubility method. Instrument and reagent 75-2 spectrophotometer (Shanghai Analytical Instrument Factory); LD4-2A centrifuge (Beijing Medical Centrifuge Factory); PHS-2-type acid meter (Shanghai Lei Magnetic Instrument Factory); electric shaker Yancheng Longgang Medical Equipment Factory); Pipemidic acid and its standard (Shandong Xinhua Pharmaceutical Factory); gluconic acid