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The advancement of Unmanned Aerial Vehicle (UAV) technology in terms of industrialprocesses and communication and networking technologies has led to an increase in their use in civil, business, and social applications. Global rules in most countries had previously limited the use of drones to military applications due to their deployment in the open air, drones are likely to be lost, destroyed, or physically hijacked. However, more recently, the presence of COVID-19 has forced the world to present new implementing measures which will also widen the use of drones in civil and commercial and social applications, especially now in the delivery of medicines for med-ical home care. In the period of required public isolation as a consequence of the SARS-COV-2 pandemic, this knowledge has become one of the principal partners in the fight against the coron-avirus. This paper offers a summary of the medical drone manufacturing, with a specific emphasis on its approval by the pharmaceutical sector to solve logistical problems in healthcare during times of sensitive need. We also discuss the numerous challenges to be met in the integration of drones to save our lives and suggest future research directions. The question that arises for this problem, how to optimize delivery medical supplies times in-home health care made up of drones? We conducted a synthesis literature review devoted to the use of UAVs in healthcare with their different aspects. A total of different research made are given to describe the role of UAV in Home healthcare with the presence of SARS-COV-2. We conclude that the drones will be able to optimize the way of elimi-nating contamination with a very high percentage (through the reduction of human contact) with the increase of the flexibility of the flight (reaching the less accessible regions every hour of the day).