论文部分内容阅读
非髓样甲状腺癌(NMTC)具有家族发病倾向,是某些家族性肿瘤综合征的组成部分,且已被近来的研究所证实。以甲状腺乳头状癌(PTC)为主的家族性肿瘤综合征,属常染色体显性遗传但其外显率降低。通过对以PTC表现为主的3种肿瘤综合征的染色体定位,进一步证明其具有家族性聚集倾向,但易感基因仍未确定。NMTC也可作为家族性腺瘤样息肉病和多发性错构瘤综台征的组成成分,但较少见,这种综合征与肿瘤抑制基因的遗传突变有关。建议对NMTC患者一级亲属进行筛查,以确诊NMTC家族。
Non-myeloid thyroid cancer (NMTC) has a familial propensity to become part of some familial tumor syndromes and has been confirmed by recent studies. Familial tumor syndromes, which are papillary thyroid carcinomas (PTC), are autosomal dominant but their penetrance decreases. The chromosomal location of the three tumor syndromes, which are mainly PTC manifestations, further proves that they have familial aggregation tendency, but the susceptibility genes have not been determined yet. NMTC can also be used as a component of familial adenomatous polyposis and multiple hamartoma syndrome, but rare, the syndrome associated with genetic mutations in tumor suppressor genes. It is recommended to screen the first degree relatives of NMTC patients to confirm the NMTC family.