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作者评价了静脉推注APSAC(anisoylated plasminogen streptokinase activator complex)对急性心肌梗塞(AMI)后死亡率的影响。本组1004例6小时内发生的AMI患者,随机接受APSAC(502例,30单位)或安慰剂(502例),6小时后静滴华法令,持续3个月。研究结果显示,30天内安慰剂组死亡61例(12.2％)、APSAC组死亡32例(6.4％)(P=0.0016)。APSA组30天内的死亡率减少了47.5％,而21.0～65.2％是有95％的把握。
The authors evaluated the effect of anisoylated plasminogen streptokinase activator complex on mortality after acute myocardial infarction (AMI). 1004 AMI patients within 6 hours of randomized APSAC (502 patients, 30 units) or placebo (502 patients) received warfarin 6 hours later for 3 months. The study showed 61 placebo deaths (12.2%) in the 30 days and 32 (6.4%) deaths in the APSAC group (P = 0.0016). Mortality in the APSA group decreased by 47.5% within 30 days, while 95% of 21.0-65.2% were in the APSA group.