论文部分内容阅读
采用邻苯三酚自氧化法和硫代巴比妥酸(TBA)荧光微量法分别测定89例癌症患者红细胞超氧化物歧化酶(RBC-SOD)活性、血浆超氧化物歧化酶(P-SOD)活性和脂质过氧化物(LPO),并与31例健康人对照,以探讨它们与癌症的关系。结果癌症患者RBC-SOD活性明显低于对照组(P<0.001),P-SOD活性和LPO明显高于对照组(P<0.05和P<0.01);随着临床分期不同,PBC-SOD活性下降趋于明显,Ⅲ-Ⅳ期显著低于Ⅰ-Ⅱ期(P<0.05),P-SOD活性和LPO明显升高,Ⅲ-Ⅳ高于Ⅰ-Ⅱ期(P<0.O5);不同部位癌症患者RBC-SOD活性、P-SOD活性和LPO均无显著性差异。提示氧化与抗氧化系统失衡与癌症发生发展有关。
The red blood cell superoxide dismutase (RBC-SOD) activity and plasma superoxide dismutase (P-SOD) were determined in 89 cancer patients using pyrogallol autoxidation and thiobarbituric acid (TBA) fluorescence microscopy. Activity and Lipid Peroxidation (LPO) were compared with 31 healthy subjects to explore their relationship with cancer. Results The RBC-SOD activity in cancer patients was significantly lower than that in the control group (P<0.001). The activity of P-SOD and LPO were significantly higher than those in the control group (P<0.05 and P<0.01). With the different clinical stages, the activity of PBC-SOD decreased. Obviously, stage III-IV was significantly lower than stage I-II (P<0.05), P-SOD activity and LPO were significantly increased, and III-IV was higher than stage I-II (P<0.05); different sites There was no significant difference in RBC-SOD activity, P-SOD activity and LPO in cancer patients. It is suggested that the imbalance between oxidation and antioxidant systems is related to the development of cancer.