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目的：探讨一氧化氮（ＮＯ）在正常妊娠时的生理作用和妊高征时的致病机理。方法：应用荧光分光光度计对正常妊娠孕妇３６例（正常妊娠组）、妊高征孕妇２３例（妊高征组）和正常未孕妇女１５例（对照组）的血浆ＮＯ进行测定比较。结果：与对照组比较，正常妊娠组血浆ＮＯ明显增高（Ｐ＜０．０１），而在孕中期增高最明显；妊高征组血浆ＮＯ明显低于正常孕晚期妇女（Ｐ＜０．０１）和对照组（Ｐ＜０．０５），ＮＯ水平随妊高征病情进展而逐渐降低。结论：ＮＯ的合成、释放减少在妊高征的病理生理变化中起重要作用
Objective: To investigate the physiological role of nitric oxide (NO) in normal pregnancy and the pathogenesis of PIH. Methods: Plasma NO was measured by fluorescence spectrophotometer in 36 pregnant women (normal pregnancy group), 23 pregnant women with PIH (pregnancy induced hypertension group) and 15 normal pregnant women (control group). Results: Compared with the control group, plasma NO in normal pregnancy group was significantly increased (P <0.01), while it increased most significantly in the second trimester of pregnancy. Plasma NO level in PIH group was significantly lower than that in normal pregnant women (P <0.01) And control group (P <0.05). The level of NO gradually decreased with the progress of PIH. Conclusion: The decrease of NO synthesis and release plays an important role in the pathophysiological changes of PIH