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目的 本文旨在探讨胃癌胃镜活检标本中增殖细胞核抗原的定量及其临床意义 ,尤其是对选定治疗方案的参考价值。方法 4 1例源自甘肃省永登县 2 2 2 6例胃癌高发人群的胃癌入本组研究 ,对胃癌活检标本行增殖细胞核抗原 (PCNA)免疫组化染色 ,IBAS图像仪定量 ,并做术后生存率对比研究。结果 4 0例手术治疗患者 1、2、3、4、5年的生存率分别为 2 2 5%、65%、52 5%、4 2 5%、35%。癌细胞中PCNA的含量与病变早晚呈正相关 ,与淋巴转移及远处转移正相关 (P <0 .0 5)。与术后生存期负相关 (P <0 .0 5)。结论 胃癌术前胃镜活检标本中PCNA的含量是胃癌恶性生物学行为的指标之一。术前行该检查可能成为围术前综合治疗 ,特别是诱导化疗的重要参考因素
Objective To investigate the quantitative and clinical significance of proliferating cell nuclear antigen in gastroscope biopsy specimens of gastric cancer, especially the reference value of the selected treatment plan. Methods Forty-one cases were studied from 26 patients with high incidence of gastric cancer in Yongdeng County, Gansu Province. The gastric cancer biopsy specimens were stained with proliferating cell nuclear antigen (PCNA) immunohistochemically, IBAS imaging instrument was quantified, and surgery was performed. Post-survival rate comparison study. RESULTS: The survival rates of 40 patients undergoing surgical treatment at 1, 2, 3, 4 and 5 years were 2 25%, 65%, 52%, 4 25% and 35%, respectively. The level of PCNA in cancer cells was positively correlated with lesions sooner or later, and positively correlated with lymphatic metastasis and distant metastasis (P < 0.05). Negative correlation with postoperative survival (P < 0.05). Conclusions The content of PCNA in gastroscope biopsy specimens before gastric cancer is one of the indicators of malignant biological behavior of gastric cancer. Preoperative examination may become a comprehensive preoperative treatment, especially for induction chemotherapy.