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目的:分析Framingham十年冠心病风险低危组、中危组、高危组患者载脂蛋白B(Apo B)/载脂蛋白A1(Apo A1)比值水平并探讨其与Framingham评分的关系。方法 :选择2011年3月至2012年12月于中山大学孙逸仙纪念医院心内科因胸痛怀疑冠心病住院者605人,分别对其进行Framingham风险评分后分为十年冠心病风险低危组、中危组、高危组3组;比较各组的血脂指标及Apo B/Apo A1比值。结果:十年冠心病风险低危组、中危组、高危组Apo B/Apo A1比值逐渐增高,差异具有统计学意义(P<0.001);Framingham评分与APOA1呈负相关(r=-0.214,P<0.001);与Apo B、Apo B/Apo A1比值呈正相关(r=0.222,P<0.001;r=0.463,P<0.001),而以Apo B/Apo A1比值相关系数最大(r=0.463)。结论:Apo B/Apo A1比值与Framingham评分密切相关,Apo B/Apo A1比值增高是冠心病发生的一个重要预测指标。
PURPOSE: To analyze the association of Apo B / Apo A1 in Framingham 10-year risk-CHD patients with low-risk, moderate-risk and high-risk groups and to explore the relationship between them and the Framingham score. Methods: From March 2011 to December 2012, 605 patients with coronary heart disease (CHD) suspected of having chest pain were admitted to the Sun Yat-sen Memorial Hospital of Sun Yat-sen University. The Framingham risk score was divided into ten years of low risk group of coronary heart disease Danger group, high-risk group three groups; comparison of blood lipid indicators and Apo B / Apo Al ratio. Results: The Apo B / Apo A1 ratio in low-risk group, moderate-risk group and high-risk group ten years increased gradually, the difference was statistically significant (P <0.001); Framingham score was negatively correlated with APOA1 (r = -0.214, (R = 0.222, P <0.001; r = 0.463, P <0.001), while the correlation coefficient of Apo B / Apo A1 ratio was the highest (r = 0.463 ). Conclusion: The Apo B / Apo A1 ratio is closely related to the Framingham score. The increased Apo B / Apo A1 ratio is an important predictor of coronary heart disease.