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目的是研究短时间模拟失重（HDT一30°）对大鼠免疫功能及垂体β-内啡肽含量的影响。采用雄性SD大鼠，随机分为正常对照组（12只），模拟失重组（15只）。结果显示，模拟失重3d后，脾淋巴细胞对刀豆蛋白A（ConA）刺激的增殖能力、白细胞介素-2（Interfeukin－2，IL－2）的活性、白细胞介素-1的产生仅有降低趋势，但无统计学意义（P＞0．05）。模拟失重7d后，脾淋巴细胞增殖能力与对照组比较，分别为12780±1748cpm，15269±1573cpm，存在显著性差异（P＜0．05）。IL－2的活性和IL－1的产生有下降趋势，但无统计学差异（P＞0．05）。模拟失重3d后垂体的β-内啡肽含量有下降趋势，作用7d后其含量为103．7±12．3ns／mg，与对照组（130．0±20．6ng／mg）比较，明显降低（P＜0．01）。这一变化同脾淋巴细胞增殖降低有相同趋势，说明T淋巴细胞增殖能力的降低可能与垂体β-内啡肽的含量减少有关。
The aim was to investigate the effect of short duration simulated weightlessness (HDT-30 °) on immune function and pituitary β-endorphin content in rats. Male SD rats were randomly divided into normal control group (n = 12) and simulated weightless group (n = 15). The results showed that after 3 days of simulated weightlessness, the proliferation of splenic lymphocytes stimulated by ConA, the activity of Interfeukin-2 (IL-2) and the production of interleukin-1 Reduce the trend, but not statistically significant (P> 0.05). Compared with the control group, the proliferative capacity of splenic lymphocytes in 7d after simulated weightlessness was 12780 ± 1748cpm and 15269 ± 1573cpm, respectively (P <0.05). IL-2 activity and IL-1 production have a downward trend, but no significant difference (P> 0.05). The content of β-endorphin in pituitary decreased after simulated weightlessness for 3 days, and the content was 103.7 ± 12.3ns / mg after 7 days, which was significantly lower than that of control group (130.0 ± 20.6ng / mg) (P <0.01). This change with the reduction of spleen lymphocyte proliferation have the same trend, indicating that the reduction of T lymphocyte proliferation may be related to the reduction of pituitary β-endorphin content.