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目的探讨MTHFRC677T基因多态性与RSA发生之间的关系。方法纳入RSA患者30例为观察组,同时纳入30例正常分娩的孕妇作为对照,以访谈的方式收集患者的一般资料及信息,采集并保存研究对象的血清标本进行MTHFRC677T基因多态性的检测,运用统计学方法进行相关性分析。结果经过检测发现,MTHFRC677T基因经酶切后有三种基因型,分别为CC纯合未突变基因型、CT杂合子基因型、TT纯合突变基因型。RSA组与对照组MTHFRC677T基因型的频率分布差异均具有统计学意义(P<0.05)。MTHFRC677T基因多态性中TT基因型发生RSA的危险度相关(OR=20.97,95%CI:1.209-3.638)。结论MTHFRC677T基因多态性与RSA的发生具有关联性,其中TT基因能够大幅提高RSA发生几率。
Objective To investigate the relationship between MTHFRC677T gene polymorphism and the occurrence of RSA. Methods Thirty patients with RSA were enrolled in the observation group and 30 pregnant women with normal delivery were enrolled as control. The general information and information of patients were collected by means of interviews. The serum samples from the study subjects were collected for the detection of MTHFRC677T gene polymorphism. Using statistical methods for correlation analysis. Results After detection, there are three genotypes of MTHFRC677T gene after digestion, which are CC homozygous non-mutant genotype, CT heterozygous genotype and TT homozygous genotype. The frequencies of MTHFRC677T genotype in RSA group and control group were significantly different (P <0.05). The TT genotype was associated with a risk of developing RSA in the MTHFRC677T gene polymorphism (OR = 20.97, 95% CI: 1.209-3.638). Conclusion MTHFRC677T gene polymorphism is associated with the occurrence of RSA, of which TT gene can significantly increase the incidence of RSA.