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目的探讨VEGF基因rs699974位点和KDR基因rs2071559、rs1531289位点,与中国北方妇女妊娠期高血压疾病(HDCP)遗传易感性的关系。方法应用聚合酶链反应-限制性片段长度多态性分型技术(PCR-RFLP)对164例中国北方地区妊娠期高血压病人和114例正常对照病人。结果 VEGF基因rs699974位点和KDR基因rs2071559、rs1531289位点中,病例组与对照组比较,P值均大于0.05,提示3个位点均无统计学意义。结论 VEGF基因rs699974位点和KDR基因rs2071559、rs1531289位点多态性与东北地区妇女HDCP遗传易感性可能无关。
Objective To investigate the relationship between rs699974 of VEGF gene and rs2071559 and rs1531289 of KDR gene and genetic susceptibility to HDCP in Chinese women in North China. Methods One hundred and sixty-four cases of hypertensive disorder complicating pregnancy in China and 114 normal controls were studied by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results In the rs699974 of VEGF gene and rs2071559 and rs1531289 of KDR gene, P values were higher than 0.05 in case group and control group, suggesting that there was no statistical significance in all three sites. Conclusion The polymorphisms of rs699974 of VEGF gene and rs2071559 and rs1531289 of KDR genes may not be related to genetic predisposition of HDCP in northeastern region.