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目的:对深圳市2008年3~6月儿童手足口病流行期间的手足口病患儿进行病原学调查及临床特征分析。方法:对2008年3~6月在该院就诊的430例手足口病病人进行调查,分析其临床特征。随机抽取83份病例的粪便标本进行肠道病毒基因检测,鉴别其基因型。结果:430例手足口病患儿中1~6岁以下占78.6%,均有口腔黏膜疹和手足皮疹,发热135例(31.4%),以低热为主,并发支气管炎45例(10.5%),肺炎23例(5.3%)。83例抽检病例中,EV 71阳性72例,CAV 16阳性7例,两者均阴性4例。结论:深圳市手足口病病原体主要为EV 71,发病人群大部分为1~6岁儿童,并发症以支气管炎和肺炎为主。
Objective: To investigate the etiological investigation and clinical characteristics of HFMD in children from March to June 2008 in Shenzhen City. Methods: 430 cases of hand, foot and mouth disease patients in our hospital from March to June in 2008 were investigated, and their clinical characteristics were analyzed. Stool specimens of 83 cases were randomly selected for detection of enterovirus genes and their genotypes were identified. Results: Of the 430 children with HFMD, 78.6% were below the age of 1 to 6 years old, both had oral mucosal rash and hand-foot rash, and 135 cases (31.4%) were fever, with low fever and 45 cases (10.5%) with bronchitis , 23 cases of pneumonia (5.3%). Among the 83 cases, 72 were EV 71 positive and 7 were CAV 16 positive, both of which were negative in 4 cases. Conclusion: The main pathogen of hand, foot and mouth disease in Shenzhen is EV 71, most of whom are children aged 1 to 6 years. The main complications are bronchitis and pneumonia.