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目的探讨围绝经期综合征妇女应激性生活事件差异的影响因素。方法对200例伴有围绝经期综合征的女性进行艾森克人格量表(EPQ)、生活事件量表(LES)、社会支持量表(SSRS)、汉密尔顿抑郁量表(HAMD),并检测血雌二醇激素(E2)及促卵泡刺激素(FSH)水平。结果根据生活事件(LES)总分是否大于20分划分为高应激组(46例)、低应激组(154例)。高应激组的外周雌二醇(E2)水平较低应激组低(t=-3.11,P<0.01)。而高应激组的卵泡刺激素(FSH)水平、LES得分、HAMD得分及神经质因子得分(EPQ-N)均比低应激组高(t=2.50,P<0.01;t=38.57,P<0.01;t=3.99,P<0.01;t=3.99,P<0.01)。高、低应激组二元Logistic分析:EPQ(N)、HAMD的回归系数β分别为0.151、0.045,P<0.01;模型拟合性:对数似然值为187.56,Nagelkerke R~2为0.20。结论影响围绝经综合征应激生活事件差异的因素包括神经质人格、抑郁状态,有必要制定个体化的精神心理咨询及干预策略以降低应激生活事件对围绝经期妇女情绪的影响。
Objective To investigate the influencing factors of the differences in stressful life events in women with perimenopausal syndrome. Methods EQIQ, LES, SSRS and HAMD were measured in 200 women with climacteric syndrome. Blood estradiol (E2) and follicle stimulating hormone (FSH) levels. The results were divided into high stress group (46 cases) and low stress group (154 cases) according to whether the total score of life event (LES) was greater than 20 points. The level of peripheral estradiol (E2) in high stress group was lower than that in stress group (t = -3.11, P <0.01). The levels of follicle stimulating hormone (FSH), LES score, HAMD score and EPQ-N in high stress group were higher than those in low stress group (t = 2.50, P <0.01; t = 38.57, P < 0.01; t = 3.99, P <0.01; t = 3.99, P <0.01). Logistic regression analysis showed that the regression coefficients β of EPQ (N) and HAMD were 0.151,0.045, P <0.01, respectively. The model fit was logarithm of 187.56 and that of Nagelkerke R ~ 2 was 0.20 . Conclusion The factors that affect the difference of life events in menopausal syndrome include neurotic personality and depression, and it is necessary to formulate individualized psychological counseling and intervention strategies to reduce the impact of stressful life events on the sentiment of perimenopausal women.