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【目的】比较阳春砂3个栽培品种长果、圆果和春选挥发油的镇痛药效。【方法】采用冰乙酸致小鼠扭体模型观察阳春砂3种挥发油的镇痛作用。【结果】阳春砂3个栽培品种的挥发油均有一定的镇痛药效,3者达到50%扭体抑制率的给药浓度分别为体积分数8.05%、8.63%、13.4%。【结论】长果和圆果阳春砂挥发油镇痛药效优于春选挥发油,可能与长果和圆果挥发油中乙酸龙脑酯含量较高有关。
【OBJECTIVE】 To compare the analgesic efficacy of volatile oil of Longchun, Yuancong and Chunxuan in three cultivars of Yangchun sand. 【Method】 The analgesic effect of three kinds of volatile oil of Yangchun sand was observed by using writhing model induced by glacial acetic acid. 【Result】 The results showed that the volatile oil of three cultivars of Yangchun sand had certain analgesic efficacy. The drug concentration of the three reached the writhing rate of 50% were 8.05%, 8.63% and 13.4% respectively. 【Conclusion】 The analgesic efficacy of Volatile Oil of Fructus Amomum and Fructus Amomum is better than that of Elaeocarpus Pentaphyllum, which may be related to the higher content of cerebroside acetate in the volatile oil of Fructus Lyon and Fructus.