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研究临床神经母细胞瘤凋亡情况，了解其与预后的关系。方法取神经母细胞瘤石腊切片，运用原位DNA末端标记法，检测凋亡细胞，计算凋亡细胞占肿瘤细胞百分比，求得凋亡指数。结果预后好的神经母细胞瘤大于预后差的神经母细胞瘤的凋亡指数。若凋亡指数大于9％，提示自发性消退。结论凋亡指数对神经母细胞瘤判断预后、指导治疗有重要价值。
To study the clinical neuroblastoma apoptosis and to understand its relationship with prognosis. Methods Paraffin sections from neuroblastoma were used to detect apoptotic cells by in situ DNA end labeling. The percentage of apoptotic cells in tumor cells was calculated and the apoptosis index was calculated. Results The prognosis of neuroblastomas with good prognosis was greater than that of neuroblastomas with poor prognosis. If the apoptotic index is greater than 9%, spontaneous regression is indicated. Conclusion Apoptosis index plays an important role in predicting prognosis and guiding treatment of neuroblastoma.