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1975年首次发现微波对血-脑屏障的作用。此后证实:低剂量(0.3mW/cm~2CW或0.03mW/cm~2PW)微波即可引起受辐射动物血-脑屏障渗透性增高,以延脑为最显著,其余依次为小脑、下丘脑和海马,大脑皮质最低。电镜观察表明,其渗透性增高的机理是内皮细胞胞饮作用加强,而非细胞间隙开放。推测微波作业人员的中枢神经系统机能障碍可能与血-脑屏障受损有关。微波对血-脑屏障作用的发现,对于微波防护、微波卫生标准的修订,以及利用微波对血-脑屏障的作用应用于疾病治疗,都有一定意义。
For the first time in 1975 found that the microwave on the blood - brain barrier. The results showed that low dose (0.3mW / cm ~ 2CW or 0.03mW / cm ~ 2PW) microwave could induce the increase of blood - brain barrier permeability in irradiated animals, with the most prominent in the brain, followed by the cerebellum, the hypothalamus and Hippocampus, the lowest cerebral cortex. Electron microscopy showed that the mechanism of increased permeability of endothelial cells is to strengthen the role of pinocytosis, but not the opening of the cell gap. Presumably central nervous system dysfunction in microwave operators may be related to impaired blood-brain barrier. The discovery of the effect of microwave on the blood-brain barrier has some significance for the application of microwave protection, revision of microwave hygienic standards, and the application of microwave on the blood-brain barrier in the treatment of diseases.