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频发性室性期前收缩(VPC_s)住院患者18例,随机分两组经先后单用及合用普罗帕酮(150mg,q8h)及普萘洛尔(20mg,q8h)至稳态后采样。普罗帕酮血药浓度—时间曲线均可用—室开放模型拟合。普罗帕酮单用时K,Cmax 及AUC 较两药合用时大(P<0.01),T_(1/2)、Vc/F 小(P<0.01,P<0.05)。本研究提示,为防止降低普罗帕酮治疗室性期前收缩的疗效,如两药必须合用时宜参考本提示并加强监护。
18 patients with frequent ventricular premature contractions (VPCs) were randomly divided into two groups and were randomly divided into two groups: propafenone (150mg, q8h) and propranolol (20mg, q8h). Propafenone plasma concentration-time curves are available - room open model fitting. K, Cmax and AUC of propafenone alone were higher than those of the two drugs (P <0.01), T 1/2 (1/2) and Vc / F (P <0.01, P 0.05). This study suggests that in order to prevent the reduction of ventricular contraction propafenone efficacy, if the two drugs must be combined should refer to this prompt and strengthen the monitoring.