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Objective To evaluate toxicity and safety of trans-resveratrol(t-RSV).Methods For assays of acute toxicity,genetic toxicity,and sub-chronic toxicity,Ames test,mice bone marrow erythrocyte micronucleus,and mice sperm abnormality were performed.Results In the acute oral toxicity tests,maximum tolerable dose(15g/kg) in male and female Kunming mice showed no toxicological signs.For 90-d feeding of t-RSV at dosage range of 167-500 mg/(kg·d) in both male and female Sprague-Dawley rats,no noticeable toxicological effects were observed.Conclusion T-RSV has no acute toxicity and no genotoxicity,no harmful effects on the human body at the tested dosage range and thus resveratrol is safe for human consumption.
Objective To evaluate toxicity and safety of trans-resveratrol (t-RSV). Methods For assays of acute toxicity, genetic toxicity, and sub-chronic toxicity, Ames test, mice bone marrow erythrocyte micronucleus, and mice sperm abnormality were performed. Results In the acute oral toxicity tests, maximum tolerable dose (15 g / kg) in male and female Kunming mice showed no toxicological signs. For 90-d feeding of t-RSV at dosage range of 167-500 mg / (kg · d) in both male and female Sprague-Dawley rats, no noticeable toxicological effects were observed. Conlusion T-RSV has no acute toxicity and no genotoxicity, no harmful effects on the human body at the tested dosage range and therefore resveratrol is safe for human consumption.