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最近已弄清铁离子在幼红细胞及网织红细胞转运的详细机制,及某些贫血与此运转机制障碍的密切关系。转铁蛋白(Tf)在N末端区和C末端区各自结合一个铁原子,然后与存在于幼红细胞或网织红细胞膜上的受体结合后,以Tf—受体复合物(Complex)的形式胞饮,运到嗜酸体(acidosome),嗜酸体的pH约5.5,铁离子自Tf解离。其后,Tf到细胞外,而受体在细胞膜再循环(recycle)。如果在血中出现此受体的自身抗体,往往妨碍Tf—受体复合物的形成,就出现小细胞、低色素性贫血的血象,但血浆铁呈高值。最近明确缺铁性贫血除机体内铁离子量绝对减少外,Tf—受体复合物胞饮过
Recently, we have elucidated the detailed mechanism of iron ion transport in erythrocytes and reticulocytes and the close relationship between some anemia and the obstacles of this mechanism of operation. Transferrin (Tf) binds to an iron atom in each of the N-terminal and C-terminal regions and binds to a receptor present on the erythroid or reticulocyte membrane in the form of a Tf-receptor complex Pooled, shipped to the acid body (acidosome), the pH of eosinophilic about 5.5, iron ions from Tf dissociation. Thereafter, Tf is extracellular and the receptor recycle in the cell membrane. If the presence of autoantibodies to this receptor in the blood often hinder the formation of the Tf-receptor complex, small blood cells with hypochromic anemia appear, but plasma iron levels are high. Recent iron deficiency anemia in addition to an absolute reduction in the body of iron ions, Tf-receptor complex drinking