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目的总结和比较特发性血小板减少性紫癜(ITP)的三组治疗方法。方法对2005年1月—2009年6月商丘市第一人民医院血液科收治86例ITP患者随机分为IVIG(丙种球蛋白)组,泼尼松组,IVIG及泼尼松联合用药组三个治疗组,比较其疗效。结果联合用药组出血症状控制时间最短,与IVIG组比较无差异(P>0.05);与泼尼松组比较有统计学意义(P<0.01);IVIG组的血小板达到有效的时间最快,与另两组相比差异有统计学意义(P<0.01);2周后血小板计数比较,联合用药组效果最好,联合用药组与波尼松组和IVIG组比较有统计学意义(P<0.01)。结论大剂量免疫球蛋白联合糖皮质激素治疗ITP是一种能快速而明显升高血小板、快速控制出血的疗效确切的治疗方法。
Objective To summarize and compare three treatment methods of idiopathic thrombocytopenic purpura (ITP). Methods From January 2005 to June 2009, 86 patients with ITP from Department of Hematology, Shangqiu First People’s Hospital were randomly divided into three groups: IVIG (gamma globulin) group, prednisone group, IVIG and prednisone combined group Treatment group, compare its efficacy. Results The bleeding time of combination group was the shortest, with no significant difference with IVIG group (P> 0.05), and the difference was statistically significant (P <0.01) with that of prednisone group. The effective time of platelet in IVIG group was the fastest, Compared with the other two groups, the difference was statistically significant (P <0.01); after 2 weeks, the platelet count was the best in the combination group and the combination group was better than the Bonedone group and IVIG group (P <0.01) ). Conclusion High-dose immunoglobulin combined with glucocorticoid treatment of ITP is a rapid and significant increase in platelets, rapid curative effect of bleeding control.