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目的研究甲基多巴结合拉贝洛尔对改善妊娠高血压患者母婴结局的作用。方法选择2013年8月至2014年8月来鄢陵县人民医院妇科就诊的96例妊娠高血压患者作为研究对象,随机分为对照组和实验组,对照组给予硫酸镁治疗,实验组给予甲基多巴联合拉贝洛尔治疗,治疗1周后观察治疗效果和不良反应,比较两组妊娠高血压患者母婴结局。结果两组治疗后舒张压、收缩压及24h尿蛋白较治疗前均显著降低,差异具有统计学意义(P<0.05)。治疗后实验组舒张压、收缩压、24h蛋白尿显著低于对照组,差异具有统计学意义(P<0.05)。实验组出现终止妊娠、胎盘早剥、胎心移位、产后出血及新生儿窒息的例数均低于对照组,其中实验组终止妊娠与胎盘早剥例数显著低于对照组,差异具有统计学意义(P<0.05)。实验组正常生产例数显著高于对照组,差异具有统计学意义(P<0.05)。两组不良反应发生情况比较无统计学意义(P>0.05)。结论甲基多巴联合拉贝洛尔治疗妊娠高血压效果显著,能显著改善妊娠高血压患者母婴结局,且无严重不良反应,安全可靠,值得在临床推广。
Objective To investigate the effect of methyldopa combined with labetalol on the improvement of maternal and infant outcome in patients with pregnancy induced hypertension. Methods Ninety-six cases of pregnancy-induced hypertension in Yanling County People’s Hospital from August 2013 to August 2014 were selected and randomly divided into control group and experimental group. The control group was treated with magnesium sulfate. The experimental group was given methyl Dopa combined with labetalol treatment, after 1 week of treatment to observe the therapeutic effect and adverse reactions, compared two groups of patients with pregnancy-induced hypertension in maternal and infant outcomes. Results After treatment, the diastolic blood pressure, systolic blood pressure and 24h urinary protein in both groups were significantly lower than those before treatment (P <0.05). After treatment, the diastolic blood pressure, systolic blood pressure and 24h proteinuria in the experimental group were significantly lower than those in the control group, with statistical significance (P <0.05). The number of termination pregnancy, placental abruption, fetal heart displacement, postpartum hemorrhage and neonatal asphyxia in the experimental group were lower than those in the control group, of which the number of termination of pregnancy and placental ablation in the experimental group was significantly lower than the control group, the difference was statistically Significance (P <0.05). The experimental group of normal production was significantly higher than the control group, the difference was statistically significant (P <0.05). There was no significant difference in adverse reactions between the two groups (P> 0.05). Conclusion Methyl dopamine combined with labetalol treatment of pregnancy-induced hypertension significantly, can significantly improve the outcome of maternal and child pregnancy in patients with hypertensive disorders, and no serious adverse reactions, safe and reliable, it is worth in the clinical promotion.