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实验动物肿瘤与人肿瘤相同,也发生癌基因的活化。选择不同种类的动物、化学物质及其给予方法,可使实验动物体内预期的器官选择性地产生肿瘤.因此研究这些动物肿瘤中的癌基因对于搞清楚人类肿瘤中癌基因活化的机制,将提供必要的基础和重要的信息。检测癌基因活化的方法主要有两类。一类是用放射线或各种致癌物诱发大鼠或小鼠肿瘤,从癌细胞中提取DNA,转化小鼠NIH3T3细胞,分析具有转化活性的活化癌基因。这种情况下伴随着DNA结构的变化,解释如何产生这种DNA的改变正是
Experimental animal tumors and human tumors the same, but also the activation of oncogenes. Choosing different types of animals, chemicals, and methods of administering them can result in the selective production of tumors in the intended organs of the laboratory animals.Therefore, to study the mechanisms by which the oncogenes in the tumors of these animals are known to activate oncogenes in human tumors will provide Necessary foundation and important information. There are two main ways to detect oncogene activation. One is the use of radiation or a variety of carcinogens induced tumor in mice or mice, DNA extracted from cancer cells, transformed mouse NIH3T3 cells, with activation activity of activated oncogenes. This is the case with changes in the structure of the DNA that explain exactly how the DNA changes