论文部分内容阅读
目的：探讨阿立哌唑与奥氮平治疗酒精所致精神障碍的临床疗效和安全性。方法将66例酒精所致精神障碍患者随机分为两组，分别口服阿立哌唑与奥氮平治疗，观察8周。治疗前后采用阳性与阴性症状量表评定临床疗效，副反应量表评定不良反应。结果治疗8周末阿立哌唑组显效率87．5％，总有效率96．9％，奥氮平组分别为88．2％、97．0％，两组显效率、总有效率比较差异无显著性（χ2＝0．19、0．00，P＞0．05）。两组不良反应较轻微，阿立哌唑组主要表现为头痛、失眠等；奥氮平组主要表现为嗜睡、体质量增加等。结论阿立哌唑与奥氮平均能快速改善酒精所致精神障碍的精神症状，总体疗效相当，安全性高，但不良反应表现形式有所不同，临床上可根据不同患者选用不同的药物治疗。“,”Objective To explore the efficacy and safety of aripiprazole vs .olanzapine in the treatment of mental disorders due to alcohol (MDA) .Methods Sixty-six MDA patients were randomly divided into two groups taking orally aripiprazole or olanzapine respectively for 8 weeks .Efficacies were assessed with the Positive and Negative Syndrome Scale (PANSS) before and after treatment and adverse reactions with the Treatment Emergent Syndrome Scale (TESS) .Results At the end of the 8th week ,obvious and total ef-fective rate were respectively 87 .5% and 96 .9% in aripiprazole and 88 .2% and 97 .0% in olanzapine group ,which showed no significant differences (χ2 =0 .19 ,0 .00 ;P>0 .05) .Adverse reactions of both groups were mild ,mainly headache ,insomnia etc .in aripiprazole and hypersomnia and weight gain etc .in olanzapine group .Conclusion Both aripiprazole and olanzapine could improve mental symptoms of MDA quickly ,their total efficacy are equivalent ,both have higher safety ,but manifestations of adverse reactions are somew hat different ,so different pharmacotherapies should be selected according to different patients clinically .