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AIM:This study aimed to determine whether metabolicsyndrome is directly or indirectly,through fatty liver,associatedwith elevated gamma-glutamyl transpeptidase (GGT) levelsin Japanese women.METHODS:From 4 366 women who received their annualhealth check-up,4 211 women were selected for analysis.All 4 211 women were negative for both hepatitis B surfaceantigen and antibody to hepatitis C virus.Clinical andbiochemical variables were examined by using univariateand multivariate analysis.RESULTS:A raised GGT level (>68 IU/L) was seen in 258(6.1%) of the 4 211 women.In univariate analysis,allvariables examined (age,body mass index,blood pressure,hemoglobin concentration,fasting blood glucose,glycosylated hemoglobin Alc,cholesterol,triglyceride,anduric acid) were associated with the elevated GGT level,whereas in multivariate analysis,four variables (age≧50 yr,hemoglobin≧14 g/dL,triglyceride≧150 mg/dL,andpresence of diabetes) were significantly and independentlyassociated with raised GGT level.Clinical variables predictingthe presence of ultrasonographic evidence of fatty liver werealso examined by multivariate analysis;four variables wereassociated with the presence of fatty liver:BMI≧25 kg/m~2,hemoglobin≧14 g/dL,triglyceride≧150 mg/dL,and uricacid ≧ 7 mg/dL.There was no significant association betweenthe raised GGT level and the presence of fatty liver.Hypertriglyceridemia was significantly and independentlyassociated with both the raised GGT level and the presenceof fatty liver.CONCLUSION:Metabolic syndrome seemed to be directly,not indirectly through fatty liver,associated with the raisedGGT level in Japanese women.
AIM: This study aimed to determine whether metabolicsyndrome is directly or indirectly, through fatty liver, associated with elevated gamma-glutamyl transpeptidase (GGT) levelsin Japanese women. METHODS: From 4 366 women who received their annualhealth check-up, 4 211 women were selected for analysis. All 4 211 women were negative for both hepatitis B surface antigen and antibody to hepatitis C virus. Clinical and biochemical variables were examined by using univariate and multivariate analysis .RESULTS: A raised GGT level (> 68 IU / L) was seen in 258 ( 6.1%) of the 4 211 women.In univariate analysis, allvariables examined (age, body mass index, blood pressure, hemoglobin concentration, fasting blood glucose, glycosylated hemoglobin Alc, cholesterol, triglyceride, anduric acid) were associated with the elevated GGT level , while in multivariate analysis, four variables (age ≧ 50 yr, hemoglobin ≧ 14 g / dL, triglyceride ≧ 150 mg / dL, and presence of diabetes) were significantly and independently associated with raised GGT level. Clinical variables predicting the presence of ultrasonographic evidence of fatty liver were administered 50% of the liver , and uricacid ≧ 7 mg / dL. There was no significant association betweenthe raised GGT level and the presence of fatty liver. Hypertriglyceridemia was significantly and independently associated with both raised GGT level and the presence of fatty liver. CONCLUSION: Metabolic syndrome seemed to be directly , not indirectly through fatty liver, associated with the raisedGGT level in Japanese women.