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目的探究新兴县不同妊娠时期妇女的甲状腺相关激素水平,为制订针对妊娠期妇女甲状腺的保护方案提供理论依据。方法 600例不同妊娠期妇女(妊娠组),其中妊娠<12周末(妊娠早期组)200例,妊娠13~27周末(妊娠中期组)200例,妊娠≥28周(妊娠晚期组)200例,常规体检非妊娠女性200例作为非妊娠组。比较各组血清甲状腺激素水平,观察比较妊娠组与非妊娠组女性甲状腺疾病发病率及不同妊娠组与非妊娠组女性甲状腺球蛋白抗体(A-TG)和过氧化物酶抗体(TPOAb)阳性率。结果妊娠组甲状腺疾病的患病率明显高于非妊娠组;妊娠组FT3、FT4、A-TG、TPOAb水平高于非妊娠组,TSH水平低于非妊娠组;各妊娠组间比较,随着妊娠时间延长,促甲状腺激素(TSH)水平逐渐上升,游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)水平以及A-TG、TPOAb的阳性率逐渐下降,差异均有统计学意义(P<0.05)。结论新兴县地区妊娠期女性甲状腺疾病的发病率高于非妊娠期的女性,对妊娠结局及预后存在一定影响,应对早中期孕妇的血清甲状腺水平加强筛查并干预,在保护孕妇健康的前提下达到优生优育的目的。
Objective To explore thyroid-related hormones in women of different gestation periods in Xinxing County, and to provide a theoretical basis for the development of thyroid protection programs for pregnant women. Methods Six hundred pregnant women of different gestations (pregnancy group) were enrolled in this study. Among them, 200 were pregnant <12 weeks old (early pregnancy), 200 were pregnant 13-27 weeks (second trimester), 200 were pregnant ≥ 28 weeks (third trimester) 200 cases of non-pregnant women in routine physical examination as non-pregnant group. Thyroid hormone levels in each group were compared. The incidence of thyroid disease and the positive rates of thyroglobulin antibody (A-TG) and peroxidase antibody (TPOAb) in pregnant women and nonpregnant women were compared between pregnant women and non-pregnant women . Results The prevalence of thyroid disease in pregnancy group was significantly higher than that in non-pregnancy group. The levels of FT3, FT4, A-TG and TPOAb in pregnancy group were higher than those in non-pregnancy group and TSH levels were lower than those in non-pregnancy group. The levels of thyroid stimulating hormone (TSH) gradually increased, the levels of free triiodothyronine (FT3), free thyroxine (FT4) and the positive rates of A-TG and TPOAb decreased gradually with the prolongation of pregnancy. The differences were statistically significant (P <0.05). Conclusions The prevalence of thyroid disease in pregnant women in Xinxing County is higher than that in non-pregnant women, which may affect the outcome and prognosis of pregnant women in Xinxing County. Serum thyroid levels should be screened and intervened in early and mid-term pregnant women. Under the premise of protecting pregnant women’s health To achieve the purpose of prenatal and postnatal care.