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目的:研究三叶肽因子1(TFF-1)在人胃癌组织中的表达及其与胃癌血管形成的关系。方法:应用免疫组织化学S-P法检测TFF-1在40例原发性胃癌及10例正常胃黏膜组织中的表达,同时检测微血管密度(MVD,以抗CD 34标记)。结果:10例正常胃黏膜组织TFF-1全部阳性表达,40例胃癌组织TFF-1表达阳性率为40％(16/40)。其阳性表达与胃癌细胞的低分化程度有关(P<0.05),而与患者的性别、肿瘤的浸润程度、淋巴结转移与否无关。胃癌组织MVD明显高于正常胃黏膜组织。TFF-1阳性及阴性表达组MVD均值分别为34.06±6.08、27.96±9.72,两组间MVD均值差异有统计学意义(P<0.05)。结论:胃癌组织中TFF-1常有表达缺失,而其高表达与肿瘤微血管形成、胃癌细胞低分化程度有关。
Objective: To investigate the expression of trefoil peptide factor 1 (TFF-1) in human gastric carcinoma and its relationship with angiogenesis. Methods: The expression of TFF-1 in 40 cases of primary gastric cancer and 10 cases of normal gastric mucosa was detected by immunohistochemical S-P method. Microvessel density (MVD) was detected by anti-CD34. Results: The TFF-1 expression in all 10 normal gastric mucosa tissues was positive. The positive rate of TFF-1 in 40 gastric cancer tissues was 40% (16/40). The positive expression was related to the poor differentiation of gastric cancer cells (P <0.05), but not with the gender, tumor infiltration, lymph node metastasis or not. MVD in gastric carcinoma was significantly higher than that in normal gastric mucosa. The mean MVD of TFF-1 positive and negative expression groups were 34.06 ± 6.08 and 27.96 ± 9.72, respectively. There was significant difference in MVD between the two groups (P <0.05). CONCLUSION: The expression of TFF-1 in gastric cancer is often lost. The high expression of TFF-1 is associated with tumor microvessel formation and poor differentiation of gastric cancer cells.