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目的:观察不同类型心绞痛患者血浆抵抗素水平的变化,以及血浆抵抗素水平与代谢指标、炎症指标等之间的相关性。方法:根据造影结果及临床表现,将114例研究对象分为不稳定型心绞痛(UAP)组(46例)、稳定型心绞痛(SAP)组(37例)和对照组(31例)。收集患者一般临床资料及生化指标;免疫比浊法检测高敏C反应蛋白(hs-CRP)水平;放免法检测血清胰岛素水平;ELISA法检测血浆抵抗素水平。结果:UAP组血浆抵抗素水平[12.09(8.40,18.08)ng/ml]显著高于SAP组[9.04(7.09,11.44]ng/ml,P<0.05],及对照组[8.71(6.58,11.56)μg/L,P<0.01]。抵抗素水平分别与年龄(R2=0.06,P<0.01)、白细胞计数(R2=0.05,P<0.05)以及hs-CRP(R2=0.05,P<0.05)独立正相关。结论:抵抗素可能通过影响系统的炎症反应参与冠心病的发生发展。
Objective: To observe the changes of plasma resistin in patients with different types of angina pectoris, and the correlation between plasma resistin level and metabolic index, inflammation index and so on. Methods: According to the radiographic findings and clinical manifestations, 114 patients were divided into unstable angina pectoris (UAP) group (46 cases), stable angina pectoris group (SAPA) (37 cases) and control group (31 cases). The clinical data and biochemical indexes of patients were collected. The levels of hs-CRP were detected by immunoturbidimetry. The level of serum insulin was detected by radioimmunoassay. The level of plasma resistin was detected by ELISA. Results: The levels of plasma resistin in UAP group [12.09 (8.40, 18.08) ng / ml] were significantly higher than those in SAP group [9.04 (7.09,11.44] ng / ml, P <0.05] μg / L, P <0.01] .The level of resistin was independent of age (R2 = 0.06, P <0.01), leukocyte count (R2 = 0.05, P <0.05) and hs-CRP Positive correlation.Conclusion: Resistin may participate in the occurrence and development of coronary heart disease by affecting the systemic inflammatory response.