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在大鼠同种器官移植前,用供体脾细胞和抗供体血清处理受体,可使移植物长期活存,这已被大量的实验所证明。这是一种具有特异性的免疫增强反应。但不同的抗血清,其效果也往往不同,同时还因在抗血清中具有能与多种抗原决定簇起反应的不同种类的抗体,以致影响对免疫增强的反应机理的研究。随着骨髓瘤细胞和抗体形成细胞的融合技术的发展,就有可能使杂交瘤细胞产生均一性的抗体。本文作者已经得到了几种
It has been demonstrated in a large number of experiments that the long-term survival of the grafts with donor splenocytes and anti-donor serum prior to allograft in rats. This is a specific immune response. However, different antisera also often have different effects, as well as different types of antibodies that react with various antigenic determinants in the antisera so as to influence the mechanism of the immune response. With the development of fusion techniques for myeloma cells and antibody-forming cells, it is possible to allow hybridoma cells to produce a homogeneous antibody. The author of this article has got several