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实验组小鼠腹腔分别注射免疫调节剂胸腺五肽(TP5)或环孢霉素(CsA),对照组注射生理盐水(NS),尔后角膜感染单纯疱疹病毒(HSV),造成小鼠实验性单纯疱疹性角膜炎模型。用裂隙灯显微镜观察小鼠角膜上皮、角膜实质、角膜新生血管、结膜和眼睑的病变变化情况。结果:种毒唇4～6天,TP5组角膜上皮和角膜实质病变比NS组严重,差异有显著性,而CsA无此作用。三组小鼠新生血管形成程度差异无显著性。且均在第8天出现高峰。TP5组和CsA组的结膜和眼睑病变,比NS组严重。因此,在临床上,应根据不同病种和不同情况,慎重使用免疫调节剂。
Experimental mice were injected intraperitoneally with immunomodulator thymopentin (TP5) or cyclosporin (CsA) respectively. The control group was injected with normal saline (NS) and corneal herpes simplex virus (HSV) Herpes keratitis model. Slit lamp microscopy of mouse corneal epithelium, corneal parenchyma, corneal neovascularization, conjunctiva and eyelid lesions. Results: For 4 ~ 6 days, the corneal epithelium and corneal parenchyma lesions of TP5 group were more serious than those of NS group, with significant difference, while CsA had no such effect. There was no significant difference in the degree of neovascularization between the three groups of mice. And the peak appeared on the 8th day. Conjunctival and eyelid lesions were more severe in the TP5 and CsA groups than in the NS group. Therefore, in clinical practice, immunomodulators should be used carefully according to different diseases and different situations.