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为研究糖蛋白ｐ１７０基因在胃癌中的表达，对８０例内镜活检及术后确诊的胃癌组织用抗生物素－过氧化酶复合物进行免疫组化染色研究。结果，胃癌组织中ｐ１７０基因表达均增强，其阳性率达６６％及７１％，并且阳性表达与胃癌组织学类型及分化程度有一定关系，管状腺癌中ｐ１７０阳性表达率高，高、中分化腺癌高于低分化、粘液腺癌、乳头状腺癌等。其分布形式基本相似，主要位于细胞浆内，其次在细胞膜内，细胞核内偶见，癌旁组织也有较强阳性表达。在转移淋巴结组中阳性表达显著高于非转移淋巴结组，提示ｐ１７０与胃癌转移密切相关。结果显示糖蛋白Ｐ１７０在胃癌组织中的表达有可能成为一种新的肿瘤标志物。
To study the expression of glycoprotein p170 gene in gastric cancer, 80 cases of endoscopic biopsy and postoperative diagnosis of gastric cancer tissue were studied by immunohistochemical staining with anti-biotin-peroxidase complex. As a result, the expression of p170 gene was increased in gastric cancer tissues, and its positive rate was 66% and 71%. The positive expression was related to the histological type and differentiation of gastric cancer. The positive expression rate of p170 in tubular adenocarcinoma was high, and the high and middle differentiation were observed. Adenocarcinoma is higher than poorly differentiated, mucinous adenocarcinoma, papillary adenocarcinoma, etc. The distribution pattern is basically similar, mainly located in the cytoplasm, secondly in the cell membrane, occasionally in the nucleus, and there is a strong positive expression in the adjacent tissue. The positive expression in the metastatic lymph node group was significantly higher than that in the non-metastatic lymph node group, suggesting that p170 is closely related to the metastasis of gastric cancer. The results showed that the expression of glycoprotein P170 in gastric cancer may become a new tumor marker.