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为了确定河南省肝癌发病的危险因素,选择152例诊断明确的原发性肝癌住院病例作为病例组,同时选择115例非肝病住院病例(排除肝胆系统疾患)作为对照组,进行病例对照研究。结果表明,HBV感染是河南省肝癌发病的重要危险因素(OR=31.22);HCV单独致肝癌的OR值为2.57,95％可信限为0.57～12.03,无统计学意义。但当HCV和HBV同时存在时,OR值为42.85,明显高于HBV或HCV单独致肝癌的危险性,呈明显的协同作用或相加作用。采用非条件Logistic回归模型分析表明HBV感染、本人肝病史、家庭肝病史、饮酒史,长期食用玉米、花生及花生类制品和精神创伤史等因素与肝癌发病有关联。
In order to determine the risk factors of liver cancer in Henan Province, 152 cases of hospitalized primary liver cancer cases were selected as the case group, and 115 cases of non-liver disease hospitalization (excluding hepatobiliary system diseases) were selected as control groups for case-control study. The results showed that HBV infection was an important risk factor for liver cancer in Henan Province (OR=31.22); the OR value of HCV alone-induced liver cancer was 2.57, and the 95% confidence limit was 0.57 to 12.03, which was not statistically significant. However, when HCV and HBV were present at the same time, the OR value was 42.85, which was significantly higher than the risk of HBV or HCV-inducing HCC alone, showing significant synergistic or additive effects. Non-conditional Logistic regression model analysis showed that HBV infection, his/her liver disease history, family history of liver disease, drinking history, long-term consumption of corn, peanuts, peanut products, and history of trauma were related to the incidence of liver cancer.