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目的探讨黄曲霉毒素人血清白蛋白加合物（ＡＦＴ－ＨＳＡ）水平与肝癌危险的关系。方法对１９９６年在江苏省海门市进行的以人群为基础的病例对照研究对象６４对血清、一般人群中１９８７年和１９９２年分别采集的血清１２份和２４份，应用夹心酶联免疫吸附测定（ＥＬＩＳＡ）法测定黄曲霉毒素血清白蛋白加合物水平。结果病例组中加合物水平明显高于对照组（ｔ＝３．５０９８，Ｐ＜０．００１），且肝癌危险度随加合物水平升高而明显增高（χ２趋势＝１５．１４２，Ｐ＝０．０００１）。比较１９８４年、１９９２年和１９９６年当地居民加合物水平，１９９２年和１９９６年明显下降。结论改粮使得当地居民摄入黄曲霉毒素量有所下降，但黄曲霉毒素污染仍可能是当地肝癌高发的危险因素之一。
Objective To investigate the relationship between the level of aflatoxin (AFT-HSA) and the risk of liver cancer. METHODS: A total of 64 population-based case-control study subjects were performed in Haimen City, Jiangsu Province in 1996 and 12 and 24 serum samples were collected in 1987 and 1992, respectively, using a sandwich enzyme-linked immunosorbent assay ( The ELISA method was used to determine the level of aflatoxin serum albumin adducts. Results The adduct levels in the case group were significantly higher than those in the control group (t=3.5098, P<0.001), and the risk of liver cancer was significantly higher with the adduct level (χ2 trend = 15.142, P =0.0001). Comparing the levels of adducts of local residents in 1984, 1992, and 1996, it has dropped significantly in 1992 and 1996. Conclusions The change in grain intake has led to a decrease in the amount of aflatoxin ingested by local residents, but aflatoxin contamination may still be one of the risk factors for the high incidence of local liver cancer.