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本文采用放射免疫分析法对43例放置IUDs后月经过多、月经正常和未放置IUDs妇女的子宫内膜前列环素(PGI_2)的代谢产物6-Keto-PGF_(1α)含量进行测定,结果放器后月经过多绸子宫内膜6-Keto-PGF_(1α)含量为15.9±1.5pg/mg组织(M±SE),明显高于放器后经量正常组的10.2±2.3pg/mg组织(P<0.05)和未放器对照组的7.2±1.3Pg/mg组织(P<0.01);但后二组差异无显著性(P>0.05)。提示放器后月经过多与子宫内膜PGI_2合成增加有密切关系;且放器妇女之MBL与PGI_2间存在正相关性。对28例妇女同一份子宫内膜分别进行纤溶酶原激活物(t-PA)和6-Keto-PGF_(1α)含量测定,发现t-PA与6-Keto-PGF_(1α)含量之间也存在正相关性。
In this paper, the content of 6-Keto-PGF_ (1α), a metabolite of endometrial prostacyclin (PGI_2) in 43 cases of IUDs who have been menorrhagia, normal menstruation and not placed in IUDs was measured by radioimmunoassay. The endometrial 6-Keto-PGF_ (1α) content of the moth silk after menstrual flow was 15.9 ± 1.5pg / mg tissue (M ± SE), which was significantly higher than 10.2 ± 2.3pg / mg tissue (P <0.05) and 7.2 ± 1.3pg / mg tissue in untreated control group (P <0.01), but there was no significant difference between the latter two groups (P> 0.05). There was a close relationship between excessive menstruation and increased synthesis of PGI_2 in endometrium after the device was put into use. And there was a positive correlation between the MBL and PGI_2 in the aspirating device. The contents of t-PA and 6-Keto-PGF_ (1α) in 28 women with the same endometrium were determined. The results showed that the contents of t-PA and 6-Keto-PGF_ (1α) There is also a positive correlation.