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1961年Chesley等均证实子痫前期妇女的姐妹中子前痫期的发生率高。1979年Cooper及Lister也指出隐性单基因可能决定子痫前期的易感性。而且,所有证据均提示单基因在其病因上的可能作用。为说明子痫前期是否遗传,Chesley等验证了150多所医院自1931至1951年间的子痫妇女,并通过产科记录追踪其女儿、外孙女和儿媳的产科史。对这些资料的分析表明此症具有高度遗传性,而且总是单基因型遗传。已知双胎、糖尿病、葡萄胎及重症Rh同种免疫均增加子痫前期的发生,这将违反单基因遗传的概念。近年许多作者指出,气候、环境因素影响着
1961 Chesley Dengjun confirmed that women with preeclampsia, the incidence of pre-eclampsia sister high. In 1979, Cooper and Lister also pointed out that the recessive single gene may determine the susceptibility to preeclampsia. Moreover, all the evidence suggests the possible role of the single gene in its etiology. To illustrate whether preeclampsia is inherited, Chesley et al. Validated eclampsia in more than 150 hospitals from 1931 to 1951 and tracked the obstetric history of her daughter, granddaughter and daughter-in-law through obstetric records. Analysis of these data shows that the disease is highly heritable and always single-genotyped. It is known that twins, diabetes mellitus, hydatidiform mole and severe Rh alloimmunization increase preeclampsia, which will violate the concept of single-gene inheritance. In recent years, many authors have pointed out that climate and environmental factors have an impact