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应用促黄体生成素释放激素(LRH)激动剂已报道可治疗子宫内膜异位症,且血清17β-雌二醇被降低可使异位的子宫内膜消退。长期注射LRH激动剂最终虽可导致促性腺激素和甾体分泌降低,但由于开始时对垂体性腺轴有刺激作用,可发生暂时性的病情加剧。相反,应用LRH拮抗剂因其可阻断而不刺激促性腺激素的释放,故能立即降低卵巢甾体激素的生成。由于新的拮抗剂合成方面取得的进展,目前已生产出增强了效应的化合物。本文目的在于研究一种LRH拮抗剂对雌大白鼠人工造成的“子宫内膜异位症”的作用。实验用SD成年大白鼠(200～240g)。穿过体壁的皮肤与肌肉做一斜向的腹壁切口。再将切下的
The application of luteinizing hormone releasing hormone (LRH) agonists has been reported to treat endometriosis, and the reduction of serum 17β-estradiol may regress the ectopic endometrium. Long-term injection of LRH agonist eventually lead to reduced gonadotropin and steroid secretion, but due to the initial stimulation of the pituitary gland axis may occur temporary exacerbations. In contrast, the use of LRH antagonists can immediately reduce the production of ovarian steroid hormones by blocking their release without stimulating gonadotropin release. Due to the progress made in the new synthesis of antagonists, compounds having enhanced effects have been produced so far. The purpose of this paper is to study the effect of a LRH antagonist on “endometriosis” in female rats. Experimental SD adult rats (200 ~ 240g). A sloping abdominal incision through the skin and muscle of the body wall. Will be cut again