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在BALB/c的生产群中,1罐(1:1交配)繁殖鼠生下2只被毛短而稀的仔鼠。该仔鼠成年后进行兄妹交配,后代出现三种表型:被毛紧披,有胸腺,生长快,繁殖力高的全毛小鼠;完全无毛,无胸腺,生长慢,性成熟晚,产仔数低的裸鼠;被毛短而稀,有胸腺,生长较快,繁殖力较高的中间态。对这些突变鼠进行交配试验,结果表明:此种突变和常规裸基因的突变一样,由单对基因控制,三种小鼠的基因型为:全毛(+/+)、全裸(nu/nu)和中间态(nu/+),在该突变鼠的生产中,可及早将全毛小鼠淘汰掉,保留裸鼠和中间态进行繁殖,使裸鼠生产简便易行。
In the BALB / c production group, 1 canine (1: 1 mating) breeding mouse gave birth to 2 short, hairy, offspring pups. The offspring mating siblings adult, offspring there are three phenotypes: tight hair drape, thymus, fast growth, high fecundity hairy mice; completely hairless, athymic, slow growth, late sexual maturity, Nude mice with low litter size; short and thin coat, thymus, faster growth, higher fertility intermediate. Mating experiments on these mutant mice showed that the mutation was controlled by a single gene, as was the case with the conventional naked gene. The genotypes of the three mice were: total hair (+ / +), nude ) And the intermediate state (nu / +). In the production of the mutant mouse, the whole hair mouse can be eliminated as early as possible, nude mice and the intermediate state can be kept for reproduction, and the nude mice can be easily and easily produced.