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由汤光等主编的《药剂人员晋升试题解答》(第一版)自1982年8月出版发行以来,一直受到广大药学工作者的欢迎和喜爱。全书共有477道试题,包括是非、选择、填充、问答、算等类型,所解答的问题涉及面广,系统性强。作者又结合我国实际情况,避免了一味追求高、堆、深以致与实际条件及客观需要相脱离的弊端,同时除对题目列出答案外,还进行了必要的注解,更有助于读者对解题的理解。所以对各级医药工作者和药学院校学生来说是一本内容丰富,理论联系实际的参考书。但阅读之后,也发现有一些不妥之处,尚须商榷。笔者现谈点个人看法,供再版时参考。一、商榷与建议 1.74页〔问题16〕写道:“风湿病人服用阿司匹林片,常伍用氧化镁或碳酸氢钠等碱性药物。”对此命题本身妥否尚需商榷:(1)有文献指出:碳酸氢钠能碱化尿液,可使阿司匹林排泄增加,以致不能维持有效血药浓度而影响疗效。如口服阿司匹林片1.0/qid,同服碳酸氢钠,使尿液pH从5.6～6.1上升到6.2～6.9,血药浓度则从27mg%降到15mg%,而对风湿病的治疗有效血药浓度需维持在30mg%水平,故服用阿司匹林片不宜使用碳酸氢钠。(2)为了减少阿司匹林对胃粘膜的刺激,现多主张与不易吸收的碱性药物如碳酸钙或氢氧化铝同服。(3)如服用阿司匹林肠溶片就不需使用碱性药物,故应注明是什么片。[冯春雷]
Since the publication of “Pharmacy Staff Promotion Questions” (the first edition), edited by Tang Guang et al., Since August 1982, it has always been welcomed and loved by the majority of pharmacy workers. The book has a total of 477 questions, including the right and wrong, choice, fill, question and answer, count and other types of questions answered a wide range of systematic and strong. Based on the actual situation in our country, the author avoids the drawbacks of blindly pursuing heights, heaps and depths so as to be separated from the actual conditions and objective needs. In addition to listing the answers to the questions, the author also makes necessary annotations and helps readers Solve the problem of understanding. So for all levels of medical workers and pharmacy students is a rich content, theory and practice of reference books. However, after reading it, I also found that there are some problems that should not be overlooked. I now talk about personal views for reference when republishing. I. DISCUSSION AND RECOMMENDATIONS 1.74 pp. [QUESTION 16] wrote: “Rheumatoid patients take aspirin tablets and often use basic drugs such as magnesium oxide or sodium bicarbonate.” The proposition itself is still open to question: (1 ) It has been reported in the literature that sodium bicarbonate can alkalize urine and increase excretion of aspirin so that the effective blood concentration can not be maintained and the curative effect is affected. Such as oral aspirin tablets 1.0 / qid, with the same sodium bicarbonate, the urine pH from 5.6 to 6.1 rose to 6.2 to 6.9, the plasma concentration decreased from 27mg% to 15mg%, while the effective therapeutic drug concentration for rheumatoid Need to maintain the level of 30mg%, it is not appropriate to take aspirin tablets using sodium bicarbonate. (2) In order to reduce the stimulation of gastric mucosa by aspirin, it is advocated that the same with nonabsorbable basic drugs such as calcium carbonate or aluminum hydroxide. (3) if taking aspirin enteric-coated tablets do not need to use alkaline drugs, it should indicate what the film. [Feng Chunlei]