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目的探讨婴幼儿肌纤维瘤病的临床病理特征、诊断及鉴别诊断。方法对3例婴儿肌纤维瘤病例进行临床病理分析及免疫组化研究并复习相关文献。结果 3例肿瘤均由呈短束状或结节状排列的梭形的细胞构成,血管丰富,呈血管外皮瘤样结构,可见到明显的淡染与深染区,1例侵及骨组织;免疫组化:肿瘤细胞Vim(+),SMA(+),CD34(-),desmin(-),EMA(-)。结论婴幼儿肌纤维瘤病是一种少见的良性间叶组织肿瘤,病理学形态特点及免疫组化染色有助于诊断及鉴别诊断。
Objective To investigate the clinicopathological features, diagnosis and differential diagnosis of myofibromatosis in infants and young children. Methods Three cases of myofibromatosis in infants were studied by clinicopathological and immunohistochemical methods and reviewed relevant literatures. Results All the 3 tumors were composed of fusiform cells arranged in short bundles or nodules. The vessels were rich in blood vessels and had a hemangiopericytoma - like structure. Obvious light and dark stained areas were observed. One case of invading bone tissues. Immunohistochemistry: tumor cells Vim (+), SMA (+), CD34 (-), desmin (-), EMA (-). Conclusion Infantile myofibromatosis is a rare benign mesenchymal tumor. Pathological features and immunohistochemical staining are helpful for the diagnosis and differential diagnosis.