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目的探讨P-cadherin和p120-catenin与乳腺癌临床病理特征的关系,并分析P-cadherin和p120-catenin表达的相关性。方法采用En Vision免疫组化法,观察P-cadherin和p120-catenin在76例乳腺浸润性非特殊类型癌中的表达情况。结果 1P-cadherin表达与组织学分级、淋巴结转移、ER、PR、HER-2和核分裂指数相关(P<0.05);p120-catenin表达与淋巴结转移、ER、PR和核分裂指数相关(P<0.05)。2P-cadherin与p120-catenin的表达负相关(P<0.05)。结论在乳腺浸润性非特殊类型癌中P-cadherin阳性表达和p120-catenin异常表达均提示预后不良,且两者具有相关性。
Objective To investigate the relationship between P-cadherin, p120-catenin and clinicopathological features in breast cancer and to analyze the correlation between P-cadherin and p120-catenin expression. Methods The En Vision immunohistochemical method was used to observe the expression of P-cadherin and p120-catenin in 76 cases of invasive breast non-special type of cancer. Results 1P-cadherin expression correlated with histological grade, lymph node metastasis, ER, PR, HER-2 and mitotic index (P <0.05); p120-catenin expression was correlated with lymph node metastasis, ER, PR and mitotic index . 2P-cadherin was negatively correlated with the expression of p120-catenin (P <0.05). Conclusion The positive expression of P-cadherin and the abnormal expression of p120-catenin in non-special invasive breast neoplasms suggest that the prognosis is poor, and the correlation between them is significant.