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目的探讨CDK8在宫颈癌及宫颈上皮内瘤变中的表达及在宫颈癌患者预后中的意义。方法选取2012-01-2015-12我院保存的石蜡组织标本,包括40例宫颈癌组织、40例宫颈上皮内瘤变组织及30例正常宫颈组织,采用免疫组化法检测CDK8在各组织中的表达情况,并检测宫颈癌组织中Ki-67、p53蛋白的表达情况,分析CDK8表达与Ki-67、p53蛋白之间的关系。结果单因素分析显示,CDK8在宫颈癌组织中的表达与淋巴结的转移有关,其表达与Ki-67表达呈正相关,其高表达与p53蛋白高表达有关,P<0.05。宫颈低度病变中的病变持续组与病变痊愈组在CDK8表达上差异无统计学意义,宫颈高度病变中的病变持续组CDK8表达明显强于病变痊愈组,差异有统计学意义,P<0.05。结论 CDK8的表达与宫颈癌的发生发展有一定的关系,检测CDK8在宫颈癌及宫颈上皮内瘤变中的表达情况有利于患者预后工作的开展。
Objective To investigate the expression of CDK8 in cervical cancer and cervical intraepithelial neoplasia and its significance in the prognosis of patients with cervical cancer. Methods The paraffin tissue specimens preserved in our hospital from January 2012 to December 2015 were collected, including 40 cases of cervical cancer, 40 cases of cervical intraepithelial neoplasia and 30 cases of normal cervical tissue. Immunohistochemistry was used to detect the expression of CDK8 in various tissues The expression of Ki-67 and p53 in cervical cancer tissues was detected, and the relationship between CDK8 expression and Ki-67 and p53 proteins was analyzed. Results Univariate analysis showed that the expression of CDK8 in cervical cancer correlated with the lymph node metastasis. The expression of CDK8 was positively correlated with the expression of Ki-67. The high expression of CDK8 was associated with the high expression of p53 protein (P <0.05). There was no significant difference in the expression of CDK8 between the persistent lesion group and the diseased lesion group. The expression of CDK8 in the persistent lesion group was significantly higher than that in the diseased lesion group, the difference was statistically significant (P <0.05). Conclusion The expression of CDK8 has some relationship with the occurrence and development of cervical cancer. Detecting the expression of CDK8 in cervical cancer and cervical intraepithelial neoplasia is beneficial to the prognosis of patients.