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目的对比观察早期应用单唾液酸四已糖神经节苷脂(GM1)干预治疗重度窒息脑损伤新生儿疗效。方法对我科2006年1月-2008年12月收治的80例重度窒息新生儿随机分为两组,分别给予脑活素和GM1进行干预,并对临床症状、头颅CT及新生儿行为神经测定评分进行统计学分析。结果两组差异具有显著意义(P<0.05)。结论尽早使用CM1能减轻新生儿缺氧缺血脑损伤,降低病死率和致残率,提高患儿生存质量。
Objective To compare the effects of early administration of monosialotetraosyl ganglioside (GM1) on neonates with severe asphyxia brain injury. Methods Eighty neonates with severe asphyxia admitted from January 2006 to December 2008 in our department were randomly divided into two groups. The neonates were given interventions of cerebrolysin and GM1, respectively. The clinical symptoms, head CT and behavioral neuroimaging Score for statistical analysis. Results The difference between the two groups was significant (P <0.05). Conclusion Early use of CM1 can reduce neonatal hypoxic-ischemic brain damage, reduce mortality and morbidity and improve children’s quality of life.